This unit is south of units 45A and 45B. All three comprise Kofa National Wildlife Refuge, which is open to hunting but subject to regulations about firearms in vehicles. Mature sheep and deer are sparse in this unit.

Once a high number of desert sheep and a healthy mule deer herd lived in Unit 45A, but numbers have dropped significantly, most likely due to drought and predation. Trophy quality also has declined. Sheep hunting is restricted to residents at this time as only one tag is offered due to low numbers of mature rams.

Rocky terrain and several sheer cliffs make for physically difficult sheep hunting. Elevations vary greatly in short distances.

The entire unit is in Kofa National Wildlife Refuge, which is open to hunting by holders of sheep or deer tags. Before hunting familiarize yourself with regulations by visiting U.S. Fish and Wildlife Service. Be especially aware of regulations that dictate how weapons can be transported in vehicles. A scarcity of roads can result in lengthy hikes. 4wd vehicles are a necessity and hiking on foot is required to get to most places.

Palo Verde mesquite, catclaw acacia and ironwood grow throughout the unit with riparian desert vegetation growing along stream beds.

Most hunters camp along dirt roads. Lodging and services are in Quartzsite and Brenda. Privately owned, developed campgrounds are in Brenda and Quartzite.