Hunting in Area 110, Grinnell, Wyoming, presents significant challenges due to limited non-wilderness land and the smart behavior of deer avoiding roads. Many hunters recommend having a knowledgeable resident or guide, especially for accessing the wilderness areas which require considerable physical fitness or assistance, such as horseback travel, due to steep and obstructed terrain. Weather greatly impacts the hunt, with movement of game influenced by cold fronts and seasonal changes, but hunters should be prepared for potential delays and the possibility of encountering grizzly bears. Insight from experienced hunters suggests planning and preparation are crucial, whether in terms of securing assistance for wilderness access or ensuring physical readiness for challenging conditions.